منابع مشابه
Molecular cloning of an immunodominant antigen of Onchocerca volvulus
We have cloned and characterized the gene for an immunodominant antigen of O. volvulus that is recognized by the sera of 96% of patients with onchocerciasis. Its 1.2-kb mRNA constitutes 0.3% of adult worm poly(A)+ RNA and its cDNA sequence reveals that it is not a highly conserved structural protein such as actin or tubulin. Similar but not identical genes occur in the genomes of related filari...
متن کاملA novel type of glutathione S-transferase in Onchocerca volvulus.
Onchocerca volvulus is a pathogenic human filarial parasite which, like other helminth parasites, is capable of evading the host's immune responses by a variety of defense mechanisms which are likely to include the detoxification and repair mechanisms of the enzyme glutathione S-transferase (GST). In this study, we show that one of the previously described GSTs from O. volvulus appears to posse...
متن کاملThe reproductive lifespan of Onchocerca volvulus in West African savanna.
The epidemiological model ONCHOSIM--a model and computer simulation program for the transmission and control of onchocerciasis--has been used to determine the range of plausible values for the reproductive lifespan of Onchocerca volvulus. Model predictions based on different lifespan quantifications were compared with the results of longitudinal skin-snip surveys undertaken in 4 reference villa...
متن کاملEmergence of Onchocerca volvulus from skin mimicking Dracunculiasis medinensis.
We describe 11 cases of suspected Dracunculus medinensis infection in which the worm recovered was identified as Onchocerca volvulus. Identification was based on morphology of the examined specimen.
متن کاملMolecular characterization and expression of Onchocerca volvulus glutathione reductase.
Glutathione metabolism represents a potential target for anti-parasite drug design. The central role of glutathione reductase (GR) in maintenance of the thiol redox state and in anti-oxidative defence has to be evaluated in more detail in order to establish the essential function of this enzyme for the survival of the filarial parasite Onchocerca volvulus. The O. volvulus GR (OvGR) gene was clo...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1980
ISSN: 0007-1161
DOI: 10.1136/bjo.64.3.223